Lars S Maier Selected Research

Calcium-Calmodulin-Dependent Protein Kinase Type 2

2/2022	Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing.
11/2021	Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure.
1/2021	Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms.
10/2020	The oral Ca/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure.
1/2020	Enhanced CaMKII-Dependent Late INa Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing.
1/2020	Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias.
1/2020	Ca2+/calmodulin-dependent protein kinase II is essential in hyperacute pressure overload.
1/2018	Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor.
10/2017	C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation.
8/2017	Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity.

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Lars S Maier Research Topics

Disease

75	Heart Failure 12/2021 - 01/2002
17	Atrial Fibrillation 01/2021 - 04/2010
15	Cardiomegaly (Heart Hypertrophy) 01/2020 - 05/2003
11	Heart Diseases (Heart Disease) 01/2020 - 01/2009
11	Cardiac Arrhythmias (Arrythmia) 01/2020 - 11/2009
10	Cardiomyopathies (Cardiomyopathy) 12/2021 - 02/2010
10	ST Elevation Myocardial Infarction 11/2021 - 08/2012
10	Myocardial Infarction 10/2021 - 12/2012
8	Hypertrophy 01/2021 - 05/2003
5	Sleep Apnea Syndromes (Sleep Apnea) 02/2022 - 01/2018
5	Cardiogenic Shock 01/2021 - 12/2017
5	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 05/2020 - 03/2010
5	Tachycardia (Tachyarrhythmias) 01/2019 - 08/2014
5	Myocardial Ischemia (Ischemic Heart Diseases) 06/2018 - 10/2009
5	Contracture 05/2010 - 01/2002
4	Infarction (Infarctions) 07/2021 - 11/2018
4	Hemorrhage 02/2021 - 12/2017
4	Unstable Angina 01/2021 - 08/2015
4	Fibrosis (Cirrhosis) 01/2021 - 10/2012
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 03/2013
4	Chest Pain (Chest Pains) 01/2021 - 01/2014
4	COVID-19 01/2021 - 01/2020
3	Mitral Valve Insufficiency (Mitral Regurgitation) 01/2022 - 01/2020
3	Chronic Renal Insufficiency 12/2021 - 06/2016
3	Hypertension (High Blood Pressure) 12/2021 - 03/2007
3	Central Sleep Apnea (Central Sleep Apnea Syndrome) 06/2021 - 05/2018
3	Infections 02/2021 - 02/2006
3	Shock 01/2021 - 01/2018
3	Coronary Artery Disease (Coronary Atherosclerosis) 12/2020 - 12/2017
3	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 09/2020 - 05/2003
3	Non-ST Elevated Myocardial Infarction 02/2020 - 03/2018
3	Systolic Heart Failure 01/2017 - 03/2011
3	Neoplasms (Cancer) 11/2013 - 06/2007
3	Acidosis 06/2013 - 12/2007
2	Acute Coronary Syndrome 04/2022 - 11/2019
2	Diabetes Mellitus 10/2021 - 01/2020
2	Acute Kidney Injury (Acute Renal Failure) 01/2021 - 01/2017
2	Albuminuria 01/2021 - 01/2017
2	Thrombocytopenia (Thrombopenia) 01/2021 - 03/2007
2	Thrombosis (Thrombus) 01/2021 - 03/2007
2	Stable Angina 02/2020 - 10/2009
2	Apnea 01/2020 - 05/2018
2	Hypoxia (Hypoxemia) 01/2020 - 03/2010
2	Stroke (Strokes) 01/2020 - 12/2017
2	Muscular Dystrophies (Muscular Dystrophy) 01/2020 - 01/2017
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2019 - 01/2016
2	Renal Insufficiency (Renal Failure) 11/2018 - 12/2017
2	Pathologic Constriction (Stenosis) 06/2018 - 05/2015
2	Sleep Deprivation 05/2018 - 03/2016

Drug/Important Bio-Agent (IBA)

41	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 02/2022 - 05/2003
17	Calcium-Calmodulin-Dependent Protein KinasesIBA 08/2017 - 12/2006
16	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2003
13	Ranolazine FDA Link 01/2018 - 10/2009
7	Protein Isoforms (Isoforms)IBA 01/2020 - 05/2003
7	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 08/2017 - 05/2003
6	SodiumIBA 01/2021 - 03/2012
5	Messenger RNA (mRNA)IBA 01/2021 - 04/2008
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2016
5	Coe Comfort (FITT)IBA 07/2020 - 08/2012
5	Pharmaceutical PreparationsIBA 01/2018 - 07/2014
5	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2017 - 11/2003
5	Adrenergic Agents (Adrenergic Drugs)IBA 10/2014 - 02/2010
4	Phosphotransferases (Kinase)IBA 10/2020 - 03/2007
4	Calmodulin (Calcium-Dependent Activator Protein)IBA 10/2020 - 03/2007
4	CalciumIBA 01/2020 - 07/2006
4	CatecholaminesIBA 12/2017 - 02/2010
3	Hexosaminidases (Hexosaminidase)IBA 01/2021 - 06/2016
3	pro-brain natriuretic peptide (1-76)IBA 01/2021 - 01/2016
3	Ion Channels (Ion Channel)IBA 01/2021 - 06/2009
3	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2020
3	empagliflozinIBA 01/2021 - 01/2018
3	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2021 - 06/2006
3	Protein Phosphatase 1IBA 12/2018 - 01/2017
3	Adrenergic Receptors (Adrenergic Receptor)IBA 05/2017 - 04/2015
3	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 08/2013 - 03/2007
3	Oxygen (Dioxygen)IBA 09/2012 - 03/2010
2	TicagrelorIBA 04/2022 - 11/2019
2	Oxidants (Oxidizing Agents)IBA 02/2022 - 03/2013
2	Troponin T (Troponin T1)IBA 11/2021 - 12/2017
2	Glucose (Dextrose)FDA LinkGeneric 05/2021 - 01/2021
2	Heparin (Liquaemin)FDA LinkGeneric 01/2021 - 03/2007
2	TroponinIBA 01/2021 - 01/2014
2	CreatinineIBA 01/2021 - 01/2020
2	Neprilysin (Neutral Endopeptidase)IBA 05/2020 - 01/2017
2	Sodium Channels (Sodium Channel)IBA 01/2020 - 01/2019
2	DysferlinIBA 01/2020 - 01/2017
2	KN 93IBA 01/2020 - 02/2006
2	Lipocalin-2IBA 01/2019 - 06/2016
2	Ethanol (Ethyl Alcohol)IBA 01/2019 - 06/2010

Therapy/Procedure

31	Therapeutics 04/2022 - 06/2007
16	Percutaneous Coronary Intervention 07/2021 - 12/2012
5	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 10/2021 - 12/2012
3	Heart-Assist Devices 09/2020 - 08/2018
3	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2020 - 12/2017
2	Patient Readmission 10/2021 - 11/2018
2	Length of Stay 02/2021 - 12/2018
2	Extracorporeal Membrane Oxygenation 01/2021 - 01/2021
2	Transplantation 01/2020 - 01/2017
2	Electric Countershock (Cardioversion) 01/2019 - 05/2015
2	Conservative Treatment 03/2018 - 08/2015